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Herbert Levine | Professor | Karl Hasselmann Professor of Bioengineering, Professor of Physics, Professor of Biosciences | | e-mail:Herbert.Levine@rice.edu | | - B.S. Physics (1976) Massachusetts Institute of Technology, Cambridge, MA
- Ph.D. Physics (1979) Princeton University, Princeton, NJ
- M.A. Physics (1977) Princeton University, Princeton, NJ
| | Primary Department | Department of Bioengineering | | |
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Department Affiliations |
| Department of BioSciencesDepartment of BioengineeringDepartment of Physics and Astronomy |
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Websites |
| Rice Faculty Page
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Research Areas |
| Theoretical Biological Physics |
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Teaching Areas |
| Biomechanics, physical biology |
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Selected Publications |
| Refereed articles |
| B. A. Camley, Y. Zhang, Y. Zhao, B. Li, E. Ben-Jacob, H.Levine and
W.-J. Rappel "Polarity mechanisms such as contact inhibition of locomotion regulate persistent rotational motion of mammalian cells on micropatterns." PNAS, 111 (2014) : 14770. |
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| B. Hu, W.J. Rappel, H. Levine "How input noise limits biochemical sensing in ultrasensitive systems." Physical Review E, 90 (2014) : 032702. |
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| D. A. Kessler, R. H. Austin, and H. Levine "Resistance to Chemotherapy: Patient Variability and Cellular Heterogeneity." Cancer Research, 74 (2014) : 4663-70. |
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| D.A. Kessler, H. Levine "Scaling solution in the large population limit of the general asymmetric stochastic Luria-Delbruck evolution process." J. Statistical Physics (2014) In Press |
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| H. Levine "Learning physics of living systems from Dictyostelium." Physical Biology, 11 (2014) : 053011. |
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| J Zimmermann, M Basan, H Levine "An instability at the edge of a tissue of collectively migrating cells can lead to finger formation during wound healing." European Physical Journal, 223 (2014) : 1259. |
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| J. Zimmermann, R. L. Hayes, M. Basan, J. N. Onuchic, W.-J. Rappel,
and H. Levine "Intercellular Stress Reconstitution from Traction Force Data." Biophysical Journal, 107 (2014) : 548. |
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| L. Sun, J.K. Noel, J.I. Sulkowska, H. Levine, J.N. Onuchic "Connecting Thermal and Mechanical Protein (Un) folding Landscapes." Biophysical Journal, 107 (2014) : 2941-52. |
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| M. Skoge, H. Yue, M. Erickstad, A. Bae, H Levine, A. Groisman, W.F. Loomis, W.-J. Rappel "Cellular memory in eukaryotic chemotaxis." PNAS, 111 (2014) : 14448-14453. |
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| M.K. Jolly, B. Huang, M. Lu, S.A. Mani, H. Levine, E. Ben-Jacob "Towards elucidating the connection between epithelial–mesenchymal transitions and stemness." J Royal Soc Interface, 11 (2014) : 20140962 . |
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| R. R. Cheng, F. Morcos, H. Levine, J. N. Onuchic "Toward rationally re-designing bacterial two-component signaling systems using coevolutionary information." PNAS, 111 (2014) : 563. |
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| A. Samuel, H. Levine, K. B. Blagoev, "Scientic priorities for the BRAIN Initiative", Nat. Meth. 10, 713 (2013) |
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| B. A. Camley, Y. Zhao, B. Li, H. Levine, W. J. Rappel, "Periodic migration in a physical model of cells on micropatterns", Phys. Rev. Lett. 111, 15810 (2013) |
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| D. Kessler and H. Levine, "Large population solution of the stochastic Luria- Delbruck evolution model", Proc. Nat. Acad. Sci. 110, 11682 (2013) |
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| H. Levine and W. J. Rappel, "The physics of eukaryotic chemotaxis"", Physics Today, Feb 2013, 24 (2013) |
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| J Feng, D.A. Kessler, E. Ben-Jacob, H. Levine, "Growth feedback as a basis for persister bistability", Proc, Nat. Acad. Sci 111, 544 (2013) |
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| M. Basan, J. Elgeti, E. Hannezo, W. J. Rappel and H. Levine. "Alignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing", Proc. Nat. Acad. Sci. 110(7):2452-9 (2013) |
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| M. Lu, M. K. Jolly, H. Levine, J. N. Onuchic, E. Ben-Jacob, ``MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination" Proc, Nat. Acad. Sci 110 18144 (2013) |
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| P. Ghosh, E. Ben-Jacob, H. Levine "Modeling cell-death patterning during biolm formation", Physical Biology 10, 066006 (2013) |
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| S. Yang, K. M. Ravikumar, H. Levine, "Energy Evaluation of beta-Strand Packing in a Fibril-Forming SH3 Domain, J. Phys. Chem B 117, 13051 (2013) |
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| B. Ho, D.A. Kessler, B-J Rappel, et al., "How input fluctuations reshape the dynamics of a biological switching system" Phys. Rev. E 86:061910; DOI:10.1103/PhysRevE.86.061910, 2012. |
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| D. Shao, H. Levine, W-J. Rappel, "Coupling actin flow, adhesion and morphology in a computational cell motility model," Proc. Natl. Acad. Sci. USA 109:6851-6856; DOI:10.1073/pnas.1203252109, 2012. |
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| E. Ben-Jacob, D.S. Coffey, H. Levine, "Bacterial survival strategies suggest rethinking cancer cooperativity," Trends in Microbiology 209:403-410; DOI:10.106/j.tim.2012.06.001, 2012. |
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| K. Takeda, D. Shao, M. Adler, et al., "Incoherent Feedforward Control Governs Adaptation of Activate Ras in a Eukaryotic Chemotaxis Pathway," Science Signaling 5, 2012. |
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| N. Bostani, D.A. Kessler, N.M. Scnerb, et al., "Noise effects in nonlinear biochemical signaling," Phys. Rev. E 85:011901; DOI:10.1103/PhysRevE85.011901, 2012. |
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| S. Nadkarni, T.M. Bartol, C.F. Stevens, et al., "Short-term plasticity constrains spatial organization of a hippocampal presynaptic terminal," Proc. Natl. Acad. Sci. USA, 109:14657-14662; DOI:10.1073/pnas.1211971109, 2012. |
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Presentations |
| Invited Talks |
| "APS March meeting, Denver." (Mar. 2014) |
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| "Biophysical Society annual meeting, San Francisco." (Feb. 2014) |
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| "CECAM meeting, EPFL Lausanne Switerland." (Aug. 2014) |
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| "ICAM meeing, UC Davis." (Jun. 2014) |
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| "ICBP, Beijing." (Jun. 2014) |
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| "NCI Physical Science Oncology program, ann. mtg.." (Mar. 2014) |
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| "Physcs of Living Systems, ann. mtg. Munich." (Jul. 2014) |
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| "Society of Mathematical Biology, Osaka, Japan." (Aug. 2014) |
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| "Systems biology workshop, Beijing." (Sept. 2014) |
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| "Invited talk, Perspectives in Nonlinear Dynamics, Hyderabad India." (July 2013) |
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| "Invited talk, meeting on Animal Swarms, Huleh valley, Israel." (March 2013) |
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| "NSF Cancer imaging workshop, Harvard Medical School, Boston." (Nov. 2013) |
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| "NSF Cell Decision-Making Workshop, Arlington VA." (June 2013) |
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| "Physics of Cancer, Physics of Living Systems meeting (Princeton)." (July 2013) |
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| "Bacterial colonies at two levels: Physical Formation and Functional Significance,." Workshop on the Physics of Bacterial Communities, Chicago, IL. (June 11) |
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| "Cell Motility--getting from the individual to collective tissue motion, ." 109th Statistical Mechanics Conference, Rutgers, NJ. (December) |
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| "Colonies of Chiral Bacteria,." American Physical Society Annual Meeting, Boston, MA. (March) |
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| "Directed Cell Motility,." Baylor College of Medicine, Houston, TX. (November) |
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| "Directed Cell Motility,." MD Anderson Systems Biology, Houston, TX. (October) |
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| "Multiscale Modeling of Biochemical Networks That Control Cell Polarization and Motility,." The Society for Mathematical Biology, Knoxville, TN. (July) With J. Allard, B. Holmes, A. Jilkine |
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| "Physics of Cancer,." KITP Physics of Cancer, Santa Barbara, CA. (July) |
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| "Presynaptic Plasticity due to Astrocytes,." Federation of European Neuroscience Societies, Barcelona, Spain. (July) |
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| "Spatiotemporal Dynamics of Eukaryotic Chemotaxis,." Vanzant Lecture Series, Rice University, Houston, TX. (December) |
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| Keynote Speaker |
| "Integrative Cancer Biology Program, annual meeting, Methodist hopsital Houston." (Apr. 2014) |
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| "Physics of Cancer, keynote talk at Radiation Research Society." (Sept, 2013) |
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| "Plenary talk, Society of Critical Care Medicine, Puerto Rico." (Jan 2013) |
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| Seminar Speaker |
| "Baylor College of Medicine, MCB seminar." (Feb. 2014) |
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| "Bioengineering seminar, Stanford." (Oct. 2014) |
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| "Biophysics seminar, Univ. of Maryland." (Nov, 2014) |
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| "Complex systems seminar, Northwestern Univ.." (Oct 2014) |
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| "LMU Munich biophysics seminar." (Jul 2014) |
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| "MD Anderson, Imaging group." (Dec. 2014) |
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| "Physics colloquium, Auburn Univ.." (Apr. 2014) |
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| "Physics colloquium, Oregon State Univ. ." (Oct. 2014) |
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| "Bacterial Interest Group, Baylor College of Medicine." (Oct 2013) |
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| "Neuroscience semimar, UTHSC Houston." (Oct. 2013) |
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| "Physics Colloquium, IISER Pune, India." (July 2013) |
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| "Physics Colloquium, RPI." (March 2013) |
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| "Physics Colloquium, UT Austin." (Feb 2013) |
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| "Physics colloquium, Univ. of Waterloo." (Oct. 2013) |
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Editorial Positions |
| Associate Editor, Physical Review Letters. American Physical Society. (2014 - 2016)
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| Editor in Chief, Physical Biology. Institute of Physics. (2014 - 2016)
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| Member of the Editorial Board, Proceedings of the National Academy of Sciences USA. (2012 - 2015)
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| Editor for Special Issue, Cancer Research. (2014 - 2014)
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Supervised Theses & Dissertations |
| Mohit Jolly, PhD Quantitative systems biology of cancer. (Thesis or Dissertation Director)
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| Jingchen Feng, PhD problems in biophysics. (Thesis or Dissertation Director)
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| Yunsong Zhang, PhD Modeling cellular and multicellular motility. (Thesis or Dissertation Director)
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| Stuart Sevier, PhD Analysis of transcriptional regulation. (Thesis or Dissertation Director)
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| Dongya Jia, PhD Problems in biophysics. (Thesis or Dissertation Director)
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| Jason George, MD/PhD Cancer drug resistance models. (Thesis or Dissertation Director)
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| Arpan Bhowmik, PhD Wave induced motility in Dictyostelium. (Thesis or Dissertation Director)
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Awards, Prizes, & Fellowships |
| Member, American Academy of Arts and Sciences (2012)
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